研究内容及研究方向
    研究领域为环境微生物、病原微生物及工业微生物的分子生物学。探索并解析与微生物抗逆、信号传导及次级代谢调控等相关的诸多功能基因，以期活用这些基因使之服务于工业，农业，医疗卫生等领域。长期以来以模型真菌为研究对象，探索了天然免疫杀菌分子一氧化氮（NO）的杀菌机制及病原菌应对NO的抗逆机制，鉴定出一系列新型NO抗性功能基因，并阐明了其抗性原理，为新型抗真菌药物开发提供了理论基础。这些成果被发表在《自然》子刊Nature Chemical Biology, Applied Environmental Microbiology和Fungal Genetics and Biology等微生物学经典杂志上。今后将继续从事与医疗卫生，食品，环境等密切相关的真菌领域的研究，具体

研究方向如下:
1.真菌的NO抗性分子机制解析及抗真菌药物杀菌靶点的定位
2.真菌的氧化应激抗性体系的解析及新型杀菌靶点的探索
3.真菌有用次级代谢产物合成途径及其调控机制的研究
4.真菌的NO合成体系及其生物学功能研究
5.新型丝状真菌蛋白表达体系的开发
6.活体检测生物探针的开发

发表论文
(1).Yao Zhou, Shengmin Zhou*, Haijun Yu, Jingyi Li, Yang Xia, Baoyi Li, Xiaoli Wang, Ping Wang*. Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. In press, doi: 10.4014/jmb.1512.12009, Feb, 2016. (共同通讯)
(2).Jia Wei, Xiaodan Cao, Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli. Journal of Microbiology and Biotechnology. 25(8): 1227-1233, 2015
(3).Shunsuke Masuo, Lisa Osada, Shengmin Zhou, Tomoya Fujita, Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.
(4).Shengmin Zhou and Naoki Takaya. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.
(5).Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura. Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1. Environmental Microbiology. 16(9):2927-2938, Sep, 2014,
(6).Shengmin Zhou, Toshiaki Narukami, ShunsukeMasuo, Motoyuki Shimizu, Tomoya Fujita, Yuki Doi, Yosuke Kamimura, Naoki Takaya. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.
(7).Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya. Microbial monomers custom-synthesized to build true bio-derived aromatic polymers. Applied Microbiology and Biotechnology. 97(20):8887-8894, Aug, 2013.
(8).Wenjing Cui, Xiaoyan Yang, Yueqin Fang, Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes. Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.
(9).Morio Miyahara, Sang-Wan Kim, Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun. Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions. Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012.
(10).Shengmin Zhou, Toshiaki Narukami, Misuzu Nameki, Tomoko Ozawa, Yosuke Kamimura, Takayuki Hoshino and Naoki Takaya. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.
(11).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, Jun-ichi Maruyama,  Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011.
(12).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi and Hirofumi Shoun. The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense. Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010.
(13).Shengmin Zhou*, Yoshito Nakanishi*, Shinya Fushinobu, Sang-Wan Kim, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010. (共同一作)
(14).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, TakayoshiWakagi, and Hirofumi Shoun. Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide. Biochemical and Biophysical Research Communications.394(3):558-561, Apr, 2010.
(15).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun. Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion? Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.
(16).Shengmin Zhou, Shinya Fushinobu, Yoshito Nakanishi, Sang-Wan Kim, Takayoshi Wakagi and Hirofumi Shoun. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae. Biochemical and Biophysical Research Communications.381 (1): 7-11, Jan, 2009.

申请中专利
4-氨基肉桂酸的制造方法。日本，专利申请号2014-021543

联系方式
电话: 021-64250135
电邮: zhoushengmin@ecust.edu.cn

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